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Updated: Jan 14, 2026

Diffusion Imaging in the Rat Cervical Spinal Cord
Published on: April 7, 2015
Interpretation of Diffusion MR Imaging Data Using Non-negative Least Squares (NNLS)
Koichi Oshio1,2, Katsuhiro Sano1, Hiroshi Kusahara3
1Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan.
Abstract:
The interpretation of abdominal diffusion images remains difficult because different types of tissue coexist within each voxel. In this study, we estimated the distribution of the diffusion coefficient (D) within each voxel using non-negative least squares from diffusion-weighted images with multiple b-values. Additionally, a method for visualizing the results as a set of images representing the D ranges was developed. This method was tested on healthy volunteers.
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