When to Hold and When to Fold: The Clinical Approach to Locoregional Recurrence After Curative Treatment of Solid...

Although retreatment of locoregional recurrence offers a critical window of opportunity for curative intervention, it poses a significant clinical challenge due to its complex nature and the scarcity of high-level evidence to guide optimal treatment. This article provides a clinical perspective on approaches to salvage treatment, emphasising the need for personalised strategies. Key considerations include determining the intent of treatment (curative vs palliative), differentiating between true recurrence and de novo primary tumours, and understanding the impact of previous treatments on salvage options. The role of adjuvant and neoadjuvant systemic therapy is also discussed, highlighting the need for further research in this area.