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Published on: May 2, 2025
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Primary epithelioid angiosarcoma of the liver
Minori Nishiya1, Keito Suzuki1, Miyako Murakawa2
1Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8519, Japan.
Clinical Journal of Gastroenterology
|October 22, 2025
Summary
A rare and aggressive primary hepatic epithelioid angiosarcoma (EAS) rapidly developed in a 67-year-old woman. Despite initial misdiagnosis as liver abscesses, autopsy confirmed this rare liver cancer, highlighting diagnostic challenges.
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Epithelioid angiosarcoma (EAS) is a rare and aggressive vascular tumor.
- Primary hepatic EAS is exceptionally uncommon, posing diagnostic challenges.
Purpose of the Study:
- To present a rare case of primary hepatic epithelioid angiosarcoma (EAS).
- To highlight the clinical, radiological, and pathological features of this rare liver malignancy.
Main Methods:
- Case report of a 67-year-old woman with rapid onset of liver masses.
- Utilized ultrasonography, contrast-enhanced ultrasonography, biopsy, and autopsy with immunohistopathology.
Main Results:
- Initial presentation mimicked liver abscesses due to rapid lesion development and inflammatory markers.
- Contrast-enhanced ultrasonography and biopsy suggested a primary liver tumor.
- Autopsy confirmed primary hepatic epithelioid angiosarcoma (EAS).
Conclusions:
- Hepatic EAS can present insidiously and be misdiagnosed.
- Multimodality imaging and histopathological analysis are crucial for accurate diagnosis.
- Early recognition and understanding of rare hepatic tumors are vital for patient outcomes.
