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Triglyceride-glucose index association with kidney function in adults; a population-based study.

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Area of Science:

  • Endocrinology and Nephrology
  • Metabolic Syndrome Research
  • Public Health and Epidemiology

Background:

  • Insulin resistance, characterized by hyperglycemia and hypertriglyceridemia, is a known risk factor for kidney dysfunction.
  • The triglyceride-glucose (TyG) index offers a potential method for assessing kidney dysfunction risk.
  • This study investigated the association between the TyG index and estimated glomerular filtration rate (eGFR) reduction in adults in western Iran.

Purpose of the Study:

  • To determine the impact of the triglyceride-glucose (TyG) index on the reduction of estimated glomerular filtration rate (eGFR) in adults.
  • To evaluate the TyG index as a predictor for kidney dysfunction in a specific population.
  • To explore the relationship between lipid and glucose metabolism markers and kidney health.

Main Methods:

  • A cross-sectional study of 9,661 adults (aged 35-65) from the Ravansar Non-Communicable Diseases (RaNCD) cohort.
  • Calculation of the triglyceride-glucose (TyG) index using the formula: ln [triglyceride (mg/dL) × fasting plasma glucose (mg/dL)/2].
  • Definition of kidney dysfunction as an eGFR < 60 ml/min per 1.73 m², with analysis of confounding factors.

Main Results:

  • The prevalence of reduced eGFR was 10.81% in the study population.
  • Individuals in the highest quartile of the TyG index exhibited significantly higher rates of hypertension, type 2 diabetes, cardiovascular disease, and dyslipidemia.
  • Elevated TyG index levels were strongly associated with an increased odds of kidney dysfunction (eGFR reduction), particularly in the third and fourth quartiles (OR: 1.47 and 1.75, respectively).

Conclusions:

  • Imbalances in lipids and glucose, as indicated by the TyG index, serve as potential markers for diminished kidney function.
  • The findings suggest that patients with elevated TyG index values should be screened for kidney disease.
  • The triglyceride-glucose (TyG) index may be a valuable tool for early identification of individuals at risk for chronic kidney disease (CKD).