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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Updated: Jan 14, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Nanotechnology in Skin Cancer Therapy: Recent Progress in Targeted Delivery.

Huang-Ping Yu1,2, Ching-Yun Hsu3,4, Jia-You Fang1,4,5

  • 1Department of Anesthesiology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

The Kaohsiung Journal of Medical Sciences
|October 23, 2025
PubMed
Summary

Nanotechnology offers advanced solutions for skin cancer treatment, improving drug delivery and targeting. This approach enhances therapeutic precision and reduces side effects for melanoma and non-melanoma skin cancers.

Keywords:
anticancer drugdrug targetingnanocarriernanomedicineskin cancer

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Area of Science:

  • Dermatology and Nanomedicine
  • Oncology
  • Materials Science

Background:

  • Skin cancer (melanoma, non-melanoma) is a global health issue.
  • Conventional therapies face challenges like poor drug penetration, toxicity, and recurrence.
  • Nanotechnology presents a promising strategy to overcome these limitations in skin cancer treatment.

Purpose of the Study:

  • To review recent advancements in nanocarrier-based therapies for skin cancer.
  • To highlight the potential of nanotechnology in enhancing drug delivery and therapeutic efficacy.
  • To discuss challenges and future directions in clinical translation.

Main Methods:

  • Review of nanocarrier platforms: liposomes, polymeric nanoparticles, dendrimers, metallic nanoparticles, and biomimetic systems.
  • Analysis of targeting strategies: passive, active, and stimuli-responsive.
  • Exploration of therapeutic applications: chemotherapy, photothermal/photodynamic therapy, gene/RNA delivery, immunotherapy.

Main Results:

  • Nanocarriers improve drug distribution and tumor targeting, enhancing therapeutic precision.
  • Various nanocarrier systems show potential in preclinical studies for diverse skin cancer treatments.
  • Successful applications demonstrated in chemotherapy, photothermal/photodynamic therapy, gene/RNA delivery, and immunotherapy.

Conclusions:

  • Nanotechnology holds significant potential to revolutionize skin cancer treatment.
  • Overcoming challenges like dermal penetration and regulatory hurdles is crucial for clinical translation.
  • Interdisciplinary collaboration is essential to develop safer, more effective nanomedicines for skin cancer patients.