Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

STARD9 and CDK5RAP2-Novel Candidate Genes for 46,XY Complete Gonadal Dysgenesis.

International journal of molecular sciences·2025
Same author

Nitric oxide functional relationships with nitrogen-containing stress metabolites: Role in plant adaptation to adverse abiotic factors.

Nitric oxide : biology and chemistry·2025
Same author

Structural Flexibility and Shape Similarity Contribute to Exclusive Functions of Certain Atg8 Isoforms in the Autophagy Process.

Molecular informatics·2025
Same author

Alternative substrate-assisted hydrolysis pathways of posttransfer editing by prokaryotic leucyl-tRNA synthetase.

The FEBS journal·2025
Same author

Lysine Acetylation of Plant α-Tubulins: Scaling Up the Local Effect to Large System Transformations.

Proteins·2025
Same author

Comparative evaluation of free radical scavenging activity and total metabolite profiles among 30 macrofungi species.

Bioresources and bioprocessing·2025

Related Experiment Video

Updated: Jan 14, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

14.2K

Computational and experimental identification of putative αTAT1 modulators: implications for nervous system function.

Oksana Rybachuk1,2, Alexey Rayevsky3,4, Mariia Styhylias3

  • 1Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.

Frontiers in Pharmacology
|October 23, 2025
PubMed
Summary
This summary is machine-generated.

Researchers identified novel compounds targeting alpha-tubulin acetyltransferase 1 (αTAT1), an enzyme crucial for microtubule regulation in the nervous system. This discovery offers potential for new therapeutic strategies for neurological disorders.

Keywords:
dockingmicrotubuleneural stem cellspharmacophoreαTAT1

More Related Videos

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

6.7K
Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

1.4K

Related Experiment Videos

Last Updated: Jan 14, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

14.2K
Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

6.7K
Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

1.4K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Pharmacology

Background:

  • Post-translational modifications (PTMs) of microtubules impact ion channels in the peripheral nervous system (PNS).
  • Alpha-tubulin acetyltransferase 1 (αTAT1) is a key enzyme regulating microtubule dynamics and stability.
  • αTAT1 is implicated in nuclear processes, cell migration, and axonal transport, highlighting its role in cytoskeletal homeostasis.

Purpose of the Study:

  • To investigate the influence of microtubule-modifying enzymes on ion channels in excitatory PNS cells.
  • To identify pharmacological agents targeting these molecular pathways.
  • To focus on αTAT1 as a potential therapeutic target due to its critical role and lack of known effectors.

Main Methods:

  • Development of a pharmacophore model for αTAT1 ligand-dependent inhibition.
  • Screening for αTAT1 modulators using molecular interaction analysis and crystal structures.
  • Assessment of cytoskeletal changes in neural stem cells via confocal microscopy.

Main Results:

  • Identification of potential αTAT1 modulators (hits).
  • Confirmation of hit compound activity using confocal microscopy.
  • Refinement of screening models and generation of new compound subsets.

Conclusions:

  • The study successfully identified and validated compounds that modulate αTAT1 activity.
  • These findings provide a foundation for developing novel therapeutics targeting microtubule-related pathways in neurological conditions.