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Dupilumab-Induced Generalized Lichen Planus: A Case Report
Hui-Shang Feng1,2, Chuang Zhang3, Yang Guo1
1Department of Dermatology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Journal of Inflammation Research
|October 23, 2025
Summary
Dupilumab therapy can paradoxically trigger generalized lichen planus (LP) in some patients. This case report highlights the potential for immune deviation, emphasizing the need for careful monitoring during biologic treatments for skin conditions.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Lichen planus (LP) is a chronic, T-cell-mediated autoimmune skin disorder with various subtypes.
- Current management of LP includes biologics and immunomodulators, but evidence on their efficacy and safety is limited.
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