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Early Immune-Inflammatory Profiling and Prognostic Biomarkers in Patients with Acute Diquat Poisoning: A Multicenter
Ping Wang1,2, Li-Ying Lin1,2, Cong-Ying Song1,2
1Department of Emergency Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, People's Republic of China.
Journal of Inflammation Research
|October 23, 2025
Summary
Acute diquat (DQ) poisoning severely disrupts immune responses. Procalcitonin (PCT) is a key predictor of mortality in DQ poisoning patients, indicating immune dysregulation.
Area of Science:
- Toxicology
- Immunology
- Clinical Medicine
Background:
- Acute diquat (DQ) poisoning is a growing concern.
- Understanding the immune system's role in DQ poisoning outcomes is crucial.
Purpose of the Study:
- To analyze immune biomarkers in acute DQ poisoning patients.
- To explore the impact of these biomarkers on patient outcomes and mortality.
Main Methods:
- Retrospective cohort study of 145 acute DQ poisoning patients.
- Comparison of immune-inflammatory parameters between patients and controls.
- Prognostic analysis based on 28-day survival, utilizing LASSO regression, logistic regression, and ROC analysis.
Main Results:
- Non-survivors had higher procalcitonin (PCT), lactate, and inflammatory cytokines (IL-6, IL-10) than survivors.
- DQ patients showed elevated WBC, neutrophils, monocytes, and cytokines, with reduced lymphocytes and T-cell subsets compared to controls.
- PCT, WBC, and lactate independently predicted mortality; PCT showed the highest discriminative value (AUC=0.88).
Conclusions:
- Acute DQ poisoning induces significant immune-inflammatory disturbances, more pronounced in non-survivors.
- PCT is the strongest independent predictor of 28-day mortality in DQ poisoning.
- Bioinformatics analysis identified immune pathways relevant for prognosis and potential therapy.
