Related Experiment Video

Updated: Jan 14, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.6K

Establishment and Evaluation of a Risk Prediction Model for Abnormal Circadian Rhythm of Blood Pressure in Young

Qinhao Chen1, Lei Shi2, Xiang Li1

  • 1Department of Electrocardiogram, 901st Hospital of the Chinese People's Liberation Army Joint Logistics Support Force, Hefei, Anhui Province, People's Republic of China.

International Journal of General Medicine
|October 23, 2025
PubMed

Insights

A new nomogram accurately predicts abnormal circadian blood pressure rhythms in young hypertension patients. Key predictors include lymphocyte-to-monocyte ratio, systemic inflammatory response index, triglycerides, and uric acid.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Biomarkers

Background:

  • Circadian blood pressure rhythm abnormalities are prevalent in young hypertensive patients.
  • Early detection and intervention are crucial for managing hypertension and preventing complications.
  • Existing predictive models may lack clinical applicability or accuracy.

Purpose of the Study:

  • To develop and validate a simple, clinically applicable nomogram for predicting abnormal circadian blood pressure rhythm in young hypertensive patients.
  • To identify independent risk factors associated with abnormal circadian blood pressure rhythms.
  • To enable early detection and timely intervention for at-risk individuals.

Main Methods:

  • A cohort of 211 young hypertensive patients was studied, with external validation using 203 additional patients.
  • Patients were classified into dipper and non-dipper groups based on 24-hour ambulatory blood pressure monitoring.
  • Multivariate logistic regression identified independent risk factors, which were used to construct and validate a nomogram.

Main Results:

  • Univariate analysis showed significant differences in lymphocyte-to-monocyte ratio (LMR), systemic inflammatory response index (SIRI), triglycerides (TG), and uric acid (UA) between groups.
  • Multivariate analysis identified decreased LMR, increased SIRI, elevated TG, and elevated UA as independent predictors.
  • The nomogram demonstrated strong predictive performance with an area under the curve (AUC) of 0.883 (internal) and 0.844 (external).

Conclusions:

  • LMR, SIRI, TG, and UA are significant independent predictors of abnormal circadian blood pressure rhythms in young hypertensive patients.
  • The developed nomogram is a rapid, accurate, and clinically valuable tool for risk stratification.
  • This nomogram facilitates early detection and intervention, potentially improving patient outcomes.
Abstract

Keywords:
circadian rhythm of blood pressurehypertensionlymphocyte-to-monocyte rationomogramsystemic immune response index

More Related Videos

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

7.5K
Human Circadian Phenotyping and Diurnal Performance Testing in the Real World10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

9.0K

Related Concept Videos

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
350
Errors occurring during blood pressure monitoring01:25

Errors occurring during blood pressure monitoring

Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
1.3K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
465
Pre-Procedural Guidelines for Assessing Blood Pressure01:10

Pre-Procedural Guidelines for Assessing Blood Pressure

Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
811
Special considerations while measuring blood pressure01:28

Special considerations while measuring blood pressure

When assessing blood pressure (BP), healthcare professionals must consider various factors and potential unexpected outcomes to ensure accurate readings and provide proper patient care. Adhering to these guidelines is essential to achieving the most reliable results.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
1.2K
Assessment of blood pressure in brachial artery(two-step method)01:23

Assessment of blood pressure in brachial artery(two-step method)

Measuring blood pressure is a fundamental skill in healthcare that aids in diagnosing and monitoring hypertension and other cardiovascular conditions. An aneroid sphygmomanometer, commonly used in clinical settings, offers a manual and precise method for blood pressure measurement. The technique for using this instrument involves specific steps that must be carefully executed to ensure accuracy. The following detailed description outlines a two-step technique for assessing blood pressure using...
1.5K