Single-Cell Sequencing Redefines Immune Heterogeneity and Communication Networks in ARDS: Toward Precision
Han-Bing Chen1, An-Min Xu2, Hai-Bo Qiu1
1Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China, seu.edu.bd.
International Journal of Genomics
|October 23, 2025
Summary
Single-cell sequencing reveals immune cell diversity and communication in acute respiratory distress syndrome (ARDS). This approach aids in identifying new therapeutic targets for this critical lung condition.
Area of Science:
- Pulmonary Medicine
- Immunology
- Genomics
Background:
- Acute respiratory distress syndrome (ARDS) presents significant mortality, exacerbated by COVID-19.
- Existing methods face challenges in detailing ARDS's complex cellular and inflammatory landscape.
- Single-cell sequencing offers a powerful tool to explore ARDS at a molecular level.
Purpose of the Study:
- To review the application of single-cell sequencing in ARDS research.
- To highlight its utility in understanding immune cell heterogeneity and inflammation.
- To identify potential therapeutic strategies for ARDS.
Main Methods:
- Systematic review of recent studies utilizing single-cell sequencing for ARDS.
- Analysis of data focusing on immune cell profiling and intercellular communication.
- Evaluation of identified therapeutic targets.
Main Results:
- Single-cell sequencing effectively elucidates immune cell heterogeneity in ARDS.
- It enables reconstruction of complex intercellular communication networks.
- Potential therapeutic targets for ARDS have been identified through this technology.
Conclusions:
- Single-cell sequencing is pivotal for dissecting ARDS pathogenesis.
- It offers a pathway toward precision medicine for ARDS patients.
- Addressing technical and translational challenges is crucial for clinical application.
