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Updated: Jan 14, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
Microbial Metabolites: An Underexploited Arsenal to Combat Antibiotic Resistance Dissemination
Xinyi Li1, Litao Wei1, Ling Li1
1State Key Laboratory of Water Pollution Control and Green Resource Recycling, School of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China.
None:
The relentless global proliferation of antibiotic resistance genes (ARGs) poses a profound threat to public health and ecological stability. Unlike static chemical pollutants, ARGs propagate through horizontal gene transfer (HGT)a dynamic biological process that facilitates the cross-taxa dissemination of resistance determinants among environmental, commensal, and pathogenic microbes. This ecological amplification of resistance undermines both clinical therapies and environmental resilience, rendering the understanding and control of ARG dissemination a critical challenge in the fight against antibiotic resistance.
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