Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Efficiency and Cost-Effectiveness of 3D-Printed Patient-Specific Guide Plate for Patients Undergoing Open-Wedge High Tibial Osteotomy: A Multicentered Randomized Controlled Trial.

Orthopaedic surgery·2026
Same author

Targeted Ruthenium-Based Anti-Inflammatory Nanoagent for Enhanced Rheumatoid Arthritis Treatment.

Exploration (Beijing, China)·2025
Same author

Pak4-mediated crosstalk between necroptotic macrophages and tendon stem/progenitor cells contributes to traumatic heterotopic ossification formation.

Bone research·2025
Same author

POSTN-Mediated Interplay of M1 Polarized Macrophage with Tendon-Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling?

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Dual-Functional Injectable Photothermal Nanohydrogel Promotes Anti-Inflammation and Bone Regeneration in Distraction Osteogenesis.

Advanced healthcare materials·2025
Same author

Drug-delivery strategies using biomaterials in the field of nerve regeneration.

Neural regeneration research·2025

Related Experiment Video

Updated: Jan 14, 2026

An Approach to Enhance Alignment and Myelination of Dorsal Root Ganglion Neurons
09:48

An Approach to Enhance Alignment and Myelination of Dorsal Root Ganglion Neurons

Published on: August 24, 2016

9.0K

An Autophagy-Sensitive Nanoplatform via Chirality-Selective Modulation for Functional Peripheral Nerve Repair and

Lingchi Kong1,2, Xiangyun Yao1,2, Xu Wang1,2

  • 1National Center for Orthopaedics, Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, P. R. China.

ACS Nano
|October 23, 2025
PubMed
Summary

Dextrorotatory iron oxide nanoparticles (D-Fe3O4) promote nerve repair in peripheral nerve injury (PNI) and diabetic peripheral neuropathy (DPN) models. This chirality-selective approach enhances Schwann cell function and nerve regeneration, offering a promising therapeutic strategy.

Keywords:
Schwann cellautophagychiralityneuropathyneurotrauma

More Related Videos

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering
10:17

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering

Published on: May 16, 2022

2.7K
Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration
09:24

Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration

Published on: May 3, 2024

1.4K

Related Experiment Videos

Last Updated: Jan 14, 2026

An Approach to Enhance Alignment and Myelination of Dorsal Root Ganglion Neurons
09:48

An Approach to Enhance Alignment and Myelination of Dorsal Root Ganglion Neurons

Published on: August 24, 2016

9.0K
Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering
10:17

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering

Published on: May 16, 2022

2.7K
Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration
09:24

Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration

Published on: May 3, 2024

1.4K

Area of Science:

  • Biomaterials Science
  • Neuroscience
  • Regenerative Medicine

Background:

  • Peripheral nerve injury (PNI) and diabetic peripheral neuropathy (DPN) lack effective treatments due to complex neuromodulation.
  • Chiral enantiomers exhibit distinct biological functions, suggesting potential for targeted therapeutic strategies.

Purpose of the Study:

  • To investigate the concept of chirality-selective neuromodulation using iron oxide nanoparticle enantiomers.
  • To evaluate the efficacy of dextrorotatory Fe3O4 enantiomers (D-Fe3O4) in promoting nerve repair in PNI and DPN models.

Main Methods:

  • Synthesis of Fe3O4 nanoparticle enantiomers.
  • Implantation of nerve scaffolds loaded with D-Fe3O4 into rat models of PNI and DPN.
  • Functional, morphological, transcriptomic, and experimental analyses to assess nerve regeneration and cellular mechanisms.

Main Results:

  • D-Fe3O4 enantiomers were endocytosed by Schwann cells, enhancing their proliferation, migration, and differentiation.
  • The autophagy-driven p-JNK/EPHA5 pathway was identified as a key mechanism in D-Fe3O4-mediated Schwann cell modulation.
  • Implants with D-Fe3O4 demonstrated accelerated structural reconstruction and improved sensory and motor function recovery in PNI and DPN models.
  • D-Fe3O4 treatment maintained target organ morphology and limb health.

Conclusions:

  • Chirality-selective neuromodulation with D-Fe3O4 offers a promising therapeutic approach for peripheral nerve repair.
  • This study expands the understanding of chiral enantiomer functions in biological systems.
  • D-Fe3O4 holds significant translational potential for treating nerve damage and maintaining organ homeostasis.