A case of cutaneous vasculitis triggered by naproxen

Area of Science:

• Dermatology
• Pharmacology

Background:

• Cutaneous vasculitis is an uncommon inflammatory condition of small skin blood vessels.
• While often self-limiting, it can lead to systemic complications if not promptly managed.

Purpose of the Study:

• To report a case of cutaneous vasculitis potentially induced by naproxen.
• To emphasize the importance of vigilant monitoring of non-steroidal anti-inflammatory drug (NSAID) use.

Main Methods:

• A case study of a 54-year-old man presenting with bilateral lower-limb purpura.
• Assessment, discontinuation of naproxen, and initiation of oral prednisolone.
• Outpatient follow-up for over one year.

Main Results:

• The patient developed purpura after starting naproxen for knee pain.
• Discontinuation of naproxen and treatment with prednisolone led to significant improvement within 2 weeks.
• No recurrence was observed during over a year of follow-up.

Conclusions:

• Naproxen may induce cutaneous vasculitis, necessitating careful prescribing and monitoring.
• Nurses play a key role in early detection, patient education, and care coordination.
• Multidisciplinary collaboration is vital for successful patient outcomes.