Association Between Hyperuricemia and Dehydration in Children With Acute Gastroenteritis

Acute gastroenteritis (AGE) is one of the most common diseases in children, and detecting dehydration status is important for managing it. Volume depletion and altered urate excretion through the gastrointestinal tract can cause hyperuricemia. This study aimed to evaluate the role of hyperuricemia in assessing the severity of dehydration in children.

This retrospective study included patients aged 7 to 18 years who were diagnosed with AGE. We used both the clinical dehydration scale and measured amount of weight loss at the time of emergency room visiting to evaluate the dehydration status. Age-based and sex-based reference values of uric acid were used to define hyperuricemia.

Of the 95 patients with AGE, 40 (42.1%) showed moderate-to-severe dehydration. Hyperuricemia was observed in 44 (46.3%) patients and was more common (95.0 vs. 10.9%, P <0.001) in patients with moderate-to-severe dehydration than in those with mild dehydration. In multivariate analysis, hyperuricemia (OR: 5.13; 95% CI: 2.453-10.526) and bicarbonate levels <15 mmol/L (OR: 3.25; 95% CI: 0.225-7.259) were significant factors associated with moderate-to-severe dehydration.

Uric acid levels were correlated with dehydration in children with AGE.