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Circulating Neoantigen- and Viral Oncoprotein-Specific CD8+ T Cells Share a Transcriptional Signature

Saumya Jani1,2, Tomas Bencomo1,3, Carolyn Shasha4

  • 1Department of Dermatology, University of Washington, Seattle, Washington.

Cancer Immunology Research
|October 23, 2025
PubMed
Summary

Researchers identified a 98-gene signature, the Signature of Peripheral Tumor-specific CD8+ T cells (SPoTT), to detect tumor-specific CD8+ T cells in blood. This signature effectively identifies T cells targeting viral oncoproteins and neoantigens across various cancers.

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