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Updated: May 13, 2026

Low-stress Route Learning Using the Lashley III Maze in Mice

Low-stress Route Learning Using the Lashley III Maze in Mice

Published on: May 23, 2010

Protocol to test path integration in mice using an L-maze behavioral assay.

Sara I Graves¹, Darren J Baker²

¹Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 1(st) ST SW, Rochester, MN 55905, USA.

|October 23, 2025

Summary

This study introduces a new L-maze protocol to assess path integration (PI) in mice. This method can help detect early neurodegenerative disease by evaluating spatial navigation abilities.

Keywords:

Behavior Model Organisms Neuroscience

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Last Updated: May 13, 2026

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Area of Science:

Neuroscience
Behavioral Science
Cognitive Science

Background:

Path integration (PI) is crucial for navigation, using self-motion cues to determine position.
Deficits in PI are linked to cognitive decline and Alzheimer's disease in humans.

Purpose of the Study:

To present a novel, dry-land L-maze protocol for assessing path integration in mice.
To provide a tool for early detection of neurodegeneration in mouse models.

Main Methods:

A three-phase protocol: habituation, training, and testing.
Utilizes a dry-land L-maze behavioral assay.
Focuses on self-motion cues for spatial estimation.

Main Results:

The protocol effectively measures path integration capabilities in mice.
It offers a standardized method for behavioral neuroscience research.

Conclusions:

This L-maze protocol is a valuable tool for studying path integration in mice.
It has potential applications in preclinical research for neurodegenerative diseases like Alzheimer's.