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Persister cells in human fungal pathogens
Yuyan Xie1,2, Weixin Ke1, Koon Ho Wong3,4,5
1State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Plos Pathogens
|October 23, 2025
Summary
Fungal persistence, a dormant state evading drug killing, impacts treatment efficacy. Understanding antifungal persistence mechanisms is crucial for developing new therapies against fungal infections.
Area of Science:
- Mycology
- Infectious Diseases
- Drug Resistance
Background:
- Microbicidal persistence is a known mechanism of antibiotic treatment failure in bacteria.
- Fungal persistence, similar to bacterial persistence, allows fungi to evade fungicidal drugs.
- Antifungal persistence within the host impairs the efficacy of current treatments.
Purpose of the Study:
- To review recent advances in antifungal persistence research.
- To elucidate shared and unique mechanisms of antifungal persistence in fungal pathogens.
- To highlight the clinical importance of understanding antifungal persistence.
Main Methods:
- Literature review of recent studies on antifungal persistence.
- Analysis of conceptual definitions and measurement methods.
- Summary of identified molecular mechanisms.
Main Results:
- Fungal persistence is a significant factor in treatment failure for fungal infections.
- Shared and unique molecular mechanisms contribute to antifungal persistence.
- Current fungicidal agents have limited efficacy against persistent fungal cells.
Conclusions:
- Further research into antifungal persistence is clinically important.
- Understanding persistence mechanisms can guide the development of novel antifungal strategies.
- Addressing fungal persistence is key to improving treatment outcomes for invasive fungal infections.
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