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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Clinical progress note: Antibiotic duration for common infections in hospitalized adults

William Aaron Manning1,2, Matthew Miller3,4

  • 1Division of Hospital Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.

Journal of Hospital Medicine
|October 23, 2025
PubMed

Insights

Shorter antibiotic courses are effective for common infections like bacteremia and pneumonia. However, challenges in implementing these shorter treatment durations persist, hindering widespread adoption.

Area of Science:

  • Infectious Diseases
  • Clinical Pharmacy
  • Antimicrobial Stewardship

Background:

  • Growing evidence supports shorter antibiotic durations for common infections.
  • Implementation barriers hinder the adoption of evidence-based shorter antibiotic courses.
  • Optimizing antibiotic therapy is crucial for combating antimicrobial resistance.

Purpose of the Study:

  • To review recent data on the effectiveness of shorter antibiotic courses.
  • To examine the application of shorter antibiotic regimens for specific infections.
  • To identify persistent barriers to the implementation of shorter antibiotic courses.

Main Methods:

  • Review of recent clinical data and evidence.
  • Analysis of treatment outcomes for specific infections.
  • Evaluation of implementation challenges in clinical practice.

Main Results:

  • Evidence supports the efficacy of shorter antibiotic courses for bacteremia.
  • Shorter regimens are effective for community-acquired pneumonia and ventilator-associated pneumonia.
  • Efficacy of shorter courses is also demonstrated for complicated urinary tract infections/pyelonephritis.

Conclusions:

  • Shorter antibiotic courses are effective for multiple common infections.
  • Implementation barriers remain a significant challenge to widespread adoption.
  • Further strategies are needed to overcome barriers and promote evidence-based prescribing.

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