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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Acute Coronary Syndrome III: Diagnostic Studies01:30

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
786
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Peripheral Artery Disease I: Introduction01:30

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
310
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Biomarker Analysis from the Compass Claudication Study - Rivaroxaban for Intermittent Claudication.

Karen Falcão Britto1, Roberto Augusto Caffaro1, Giuliano Giova Volpiani1

  • 1Santa Casa de São Paulo School of Medical Sciences, São Paulo, SP, Brazil.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|October 23, 2025
PubMed
Summary
This summary is machine-generated.

Rivaroxaban plus aspirin did not alter coagulation or inflammatory biomarkers in patients with peripheral artery disease and intermittent claudication compared to aspirin alone. This biomarker analysis found no significant differences between the treatment groups after 24 weeks.

Keywords:
biomarkersintermittent claudicationperipheral artery diseaserivaroxaban

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Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Biomarker Research

Background:

  • Peripheral artery disease (PAD) and intermittent claudication impact walking ability.
  • Coagulation and inflammatory biomarkers may offer prognostic insights in PAD.
  • Previous studies suggest rivaroxaban plus aspirin improves walking distance in PAD patients.

Purpose of the Study:

  • To investigate the effect of rivaroxaban plus aspirin versus aspirin alone on coagulation and inflammatory biomarkers.
  • To determine if these biomarkers can serve as prognostic indicators in intermittent claudication.
  • To inform clinical decision-making in PAD management.

Main Methods:

  • A prospective, randomized, multicenter biomarker substudy.
  • Inclusion of 36 patients with PAD and intermittent claudication from two treatment arms (rivaroxaban + aspirin vs. aspirin alone).
  • Measurement of plasma biomarkers including D-dimer, von Willebrand factor, thrombin generation potential, PAI-1, TAFI, and CRP at baseline and 24 weeks.

Main Results:

  • No significant differences in assessed coagulation or inflammatory biomarkers were found between the rivaroxaban plus aspirin group and the aspirin alone group.
  • Biomarker levels remained comparable between the treatment arms after 24 weeks of intervention.
  • The addition of rivaroxaban to aspirin did not lead to detectable changes in these specific biomarkers.

Conclusions:

  • Treatment with rivaroxaban plus aspirin did not significantly alter coagulation or inflammatory biomarkers compared to aspirin alone in patients with intermittent claudication.
  • The study did not identify differences in these biomarkers that could explain the observed improvements in walking distance.
  • Further research may be needed to identify other biomarkers or mechanisms involved in PAD treatment response.