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The enedioic acid analog 326E alleviates metabolic dysfunction-associated steatohepatitis via dual targeting at ACLY

Zhifu Xie1, Long Cheng1, Yue Hu2

  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.

Cell Metabolism
|October 23, 2025
PubMed

Keywords:
326EACLYPPARαfatty acid β-oxidationlipogenesismetabolic dysfunction-associated steatohepatitisphase 1b/2a clinical trial

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