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Updated: Jan 14, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

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Emerging insights of fibrinogen glycation in cardiovascular disorders: A review

K Ameera1, Garima Choraria2, Shaik Basha1

  • 1Department of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal - 576104, Karnataka, India.

International Journal of Biological Macromolecules
|October 23, 2025
PubMed

Insights

Protein glycation alters fibrinogen, increasing its thrombotic potential and contributing to cardiovascular disease (CVD). Glycated fibrinogen promotes thrombosis, inflammation, and oxidative stress, highlighting its role in CVD pathophysiology.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Cardiovascular diseases (CVDs) are a leading cause of global mortality, driven by metabolic, vascular, and inflammatory factors.
  • Protein glycation is increasingly recognized as a key molecular pathway implicated in the development of CVDs.

Purpose of the Study:

  • To comprehensively review the biochemistry of protein glycation.
  • To elucidate the molecular mechanisms by which glycated fibrinogen contributes to CVD.
  • To summarize characterization techniques for glycated fibrinogen.

Main Methods:

  • Literature review and synthesis of existing research on protein glycation and fibrinogen.
  • Analysis of biochemical pathways and molecular mechanisms.
  • Evaluation of characterization techniques for glycated proteins.

Main Results:

  • Glycation alters fibrinogen structure and function, reducing polymerization and altering clot architecture.
  • Glycated fibrinogen exhibits increased resistance to fibrinolysis and enhanced thrombotic potential.
  • Glycated fibrinogen contributes to oxidative stress, systemic inflammation, and immune dysregulation.

Conclusions:

  • Glycated fibrinogen is a significant mediator in the pathophysiology of cardiovascular diseases.
  • Glycated fibrinogen holds potential as a biomarker for CVD risk assessment.
  • Targeting glycated fibrinogen may offer therapeutic strategies for CVD.

Keywords:
Advanced glycation end productsCardiovascular diseasesFibrinogenGlycation

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