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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
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Cannabis Perturbs Dynamic Brain States.

Katharina S Lege1, Pablo Mallaroni1, Sepehr Mortaheb2

  • 1Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.

Biological Psychiatry
|October 23, 2025
PubMed
Summary
This summary is machine-generated.

Cannabis use alters brain network dynamics, affecting cognitive performance differently in occasional versus chronic users. These changes are linked to cannabinoid receptor 1 density and neuroadaptations.

Keywords:
CB(1) receptorsCannabisCognitionConnectomicsNeuroadaptationfMRI

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Area of Science:

  • Neuroimaging
  • Cognitive Neuroscience
  • Cannabis Research

Background:

  • Cannabis effects on cognition vary by usage frequency.
  • Chronic cannabis use may lead to neuroadaptations and tolerance.
  • Mechanisms of cannabis-induced neuroadaptation are not fully understood.

Purpose of the Study:

  • Investigate acute and persistent effects of vaporized cannabis on brain dynamics.
  • Assess the association between brain network changes, attentional performance, and cannabinoid receptor 1 (CB1) density.
  • Compare effects in occasional versus chronic cannabis users.

Main Methods:

  • Placebo-controlled neuroimaging trial using functional resting-state data.
  • Analysis of dynamic functional connectivity during cannabis intoxication.
  • Measurement of attentional performance and CB1 receptor density.

Main Results:

  • Cannabis intoxication acutely altered brain network organization, reducing hyperconnected states in both user groups.
  • Chronic users showed decreased brain network segregation, indicating persistent neuroadaptations.
  • Impaired attention correlated with dynamic brain reconfiguration; effects were linked to CB1 receptor density.

Conclusions:

  • Cognitive impairment from cannabis is influenced by network changes and CB1 density.
  • Neural dynamics and individual neuroadaptations are crucial for understanding cannabis effects.
  • Findings are relevant for therapeutic, legal, and societal contexts of cannabis use.