Association between sleep duration at 12 and 18 months and epilepsy risk at 2-3 years: the Japan Environment and
Yuto Arai1, Tohru Okanishi2, Toshio Masumoto3
1Child Neurology, Tottori Daigaku Igakubu Fuzoku Byoin, Yonago, Japan m08106@yahoo.co.jp.
Insights
Infants sleeping less than 11 hours daily face a higher risk of developing epilepsy. This study emphasizes the importance of adequate sleep for long-term childhood neurological health.
Area of Science:
- Pediatric Neurology
- Sleep Medicine
- Epidemiology
Background:
- Sleep deprivation impacts neurobehavioral function in children.
- The relationship between infant sleep duration and epilepsy risk is not well-established.
Purpose of the Study:
- To investigate the association between sleep duration at 12 and 18 months of age and the risk of epilepsy at 2 and 3 years.
- To determine if insufficient sleep in infancy increases the likelihood of developing epilepsy in early childhood.
Main Methods:
- Analysis of data from the Japan Environment and Children's Study (JECS), a large-scale birth cohort.
- Retrospective analysis of 86,441 children, assessing epilepsy risk for those sleeping under 11 hours per night.
- Utilized multivariate logistic regression to identify significant associations.
Main Results:
- A sleep duration under 11 hours at 12 months was significantly associated with epilepsy incidence at 2 and 3 years (aOR 2.02 and 1.98, respectively).
- Insufficient sleep at both 12 and 18 months was linked to a higher risk of epilepsy at 3 years (aOR 2.77).
Conclusions:
- Infant sleep duration may be a significant factor in the development of childhood epilepsy.
- Early life sleep interventions are crucial for promoting long-term neurological well-being and potentially reducing epilepsy risk.
Background:
Sleep deprivation has notable effects on neurobehavioural functioning in children. However, the link between sleep duration and the risk of developing epilepsy in early childhood remains uncertain. The aim of this study was to explore the association between sleep duration at 12 and 18 months and the risk of epilepsy at 2 and 3 years of age.
Methods:
Data from the Japan Environment and Children's Study (JECS), a largescale birth cohort, were analysed. We assessed the risk of epilepsy at 2 and 3 years of age among children sleeping under 11 hours per night, the minimum recommended by the American Academy of Sleep Medicine for 1-2 year olds.
Results:
Overall, 86 441 children were retrospectively analysed. Of these, 8786 (10.2%) and 12 850 (14.9%) slept for less than 11 hours at 12 months and 18 months, respectively. Multivariate logistic regression showed that a sleep duration of less than 11 hours at 12 months remained significantly associated with epilepsy incidence at 2 and 3 years (adjusted OR (aOR) 2.02, 95% CI 1.01 to 4.01, p=0.045; aOR 1.98, 95% CI 1.15 to 3.41, p=0.013). Furthermore, a sleep duration of less than 11 hours at 12 and 18 months was significantly associated with epilepsy incidence at 3 years (aOR 2.77, 95% CI 1.28 to 6.01, p=0.010).
Conclusions:
Insufficient sleep in infancy may be linked to epilepsy later in childhood. These findings highlight the importance of sleep interventions during early life to improve long-term neurological health.
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