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Medical Therapies of Cushing's Disease-Part 1
Yair Schwarz1, Elisabeth Nowak2, Reut Halperin3
1Division of Endocrinology, Diabetes and Metabolism, Sheba Medical Center, Ramat Gan; Dina Recanati School of Medicine, Reichman University, Herzliyya, Israel; Section of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands.
Abstract:
Cushing's disease (CD) is an endogenous hypercortisolism state caused by an adrenocorticotropic hormone secreting pituitary adenoma. CD is associated with vast comorbidities and has a significant detrimental effect on quality of life as well as longevity. First line treatment for CD is transsphenoidal surgery (TSS) while medical therapy is an important second line treatment in cases of TSS failure or infeasibility. Current existing medications for CD target different processes related to CD including the corticotroph adenoma, cortisol adrenal manufacturing mechanisms, and glucocorticoid receptor blockage and widely differ in advantages as well as adverse effects. In depth acquaintance with the specific characteristics of each drug is needed in order to provide patients with the appropriate therapy according to their specific needs.
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