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Prevalence and risk factors of paediatric acute ischaemic stroke: a systematic review and meta-analysis protocol
Ping Wang1, Shenglei Jiang2,3, Guolian Shen1
1Department of Pediatric, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, People's Republic of China.
Insights
This systematic review will investigate the prevalence and risk factors of paediatric acute ischaemic stroke (AIS). Findings will inform prevention and management strategies for this rare but severe childhood neurological condition.
Area of Science:
- Neurology
- Pediatrics
- Public Health
Background:
- Paediatric acute ischaemic stroke (AIS) is a rare, severe neurological condition with significant long-term disability and societal impact.
- Distinct clinical features and etiologies in children compared to adults complicate early identification and prevention.
- A comprehensive understanding of AIS prevalence and risk factors in children is crucial for effective clinical strategies.
Purpose of the Study:
- To systematically review the existing literature on the prevalence of paediatric AIS.
- To identify and analyze the key risk factors associated with paediatric AIS.
- To provide an evidence base for improved prevention and management of paediatric AIS.
Main Methods:
- Systematic literature search across PubMed, Embase, Web of Science, and Cochrane Library until August 2025.
- Inclusion of observational studies reporting paediatric AIS prevalence or risk factors.
- Data extraction and quality assessment using the Newcastle-Ottawa scale, with meta-analysis performed using RevMan 5.4 and StataMP 16.0.
Main Results:
- This section is to be populated upon study completion.
Conclusions:
- This section is to be populated upon study completion.
Introduction:
Paediatric acute ischaemic stroke (AIS) is a rare but severe neurological condition, often leading to long-term disability and considerable societal burden. Compared with adults, paediatric AIS exhibits distinct clinical characteristics and aetiologies, making early identification and prevention more challenging. This study aims to systematically review the prevalence and risk factors of paediatric AIS, providing a comprehensive evidence base for clinical prevention and management.
Methods And Analysis:
A systematic search will be conducted across major databases, including PubMed, Embase, Web of Science and Cochrane Library, from inception to August 2025. We will include observational studies reporting on the prevalence or risk factors of paediatric AIS. Two independent reviewers will screen the literature, extract data and assess study quality using the Newcastle-Ottawa scale. Meta-analysis will be performed using RevMan 5.4 and StataMP 16.0. Heterogeneity will be evaluated using the I² statistic, and subgroup and sensitivity analyses will be conducted as needed. The Grading of Recommendations Assessment, Development and Evaluation system will be used to assess the quality of evidence.
Ethics And Dissemination:
Because no patients were involved, ethical approval was not required. The final results of this research will be submitted to a peer-reviewed journal or presented at relevant conferences, and any deviations from this protocol will be recorded and explained in the final report.
Registration:
This study has been registered in the PROSPERO (PROSPERO Registration Number: CRD420251067538).
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