Levofloxacin-induced myopathy of the iliac and gluteal muscles

Levofloxacin-induced myopathy is a relatively under-recognized adverse effect. Here, we present a case of myopathy affecting the iliac and gluteal muscles caused by the administration of levofloxacin. A man in the 70s was admitted to the hospital with bilateral thigh pain and difficulty walking following levofloxacin use. Creatine kinase levels were not elevated, but MRI revealed inflammation in the iliac and gluteal muscles. His symptoms improved after levofloxacin discontinuation, and he may have had levofloxacin-induced myopathy. This case report seeks to raise awareness of levofloxacin-induced myopathy by adding to the small number of reports in the literature. Levofloxacin-induced myopathy should be considered in the differential diagnosis when there are musculoskeletal symptoms in elderly patients receiving levofloxacin.