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Related Concept Videos

Nursing Assessment of the Genitourinary System I: Health History01:21

Nursing Assessment of the Genitourinary System I: Health History

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The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
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Exploring Factors Associated with Late Urinary Toxicity After Prostate Stereotactic Body Radiotherapy: Findings from

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European Urology
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Higher baseline urinary symptoms and prior acute toxicity predict late urinary issues after prostate SBRT. Patients with worse symptoms need counseling on elevated risks and consider moderate hypofractionation.

Keywords:
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Area of Science:

  • Oncology
  • Radiation Oncology
  • Urology

Background:

  • Stereotactic body radiotherapy (SBRT) is a growing treatment for localized prostate cancer.
  • Late urinary toxicity is a known concern within two years post-SBRT.

Purpose of the Study:

  • To identify factors predicting late urinary toxicity following SBRT for prostate cancer.
  • To inform patient counseling and treatment planning for SBRT.

Main Methods:

  • Analysis of PACE-B SBRT patients with dose-volume histogram data.
  • Logistic regression to identify predictors of Common Terminology Criteria for Adverse Events (CTCAE) grade 2+ urinary toxicity and International Prostate Symptom Score (IPSS) increase at 2 years.

Main Results:

  • 12% of patients experienced grade 2+ urinary toxicity at 2 years.
  • Predictors included higher baseline IPSS, baseline urinary medication use, and acute urinary toxicity.
  • Conventional LINAC-SBRT without fiducials and CyberKnife SBRT showed lower odds of toxicity compared to CL-SBRT with fiducials, but this was not consistent across all endpoints.

Conclusions:

  • Baseline urinary symptoms and acute toxicity are significant predictors of late urinary toxicity after prostate SBRT.
  • Patients with pre-existing urinary issues should be informed of their increased risk.
  • Treatment technique may influence toxicity, warranting further investigation into prescribing practices.