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Updated: May 11, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
Magnetic Induction Heating Enables On-Demand Drug Release via Diels-Alder Polymeric Nanocarriers
Nanami Fujisawa1,2, Mitsuhiro Ebara1,2, James J Lai3,4
1Research Center for Macromolecules and Biomaterials, National Institute for Materials Science, Tsukuba 305-0044, Japan.
None:
As a stimulus-responsive drug release system, we developed Diels-Alder (DA) induction-activated magnetic nanoparticles (DiMaN). Functionalization of polymer-coated magnetic nanoparticles (mNPs) with drugs via thermoreversible DA coupling enabled release through retro-Diels-Alder (rDA) cleavage upon heating. The (pDMAm-co-pFMA)-b-pAAc polymer supported mNP formation and drug binding. DA coupling with maleimide-functionalized drugs was verified by 1H NMR, showing distinct exo (3.23 ppm) and endo (3.48 ppm) signals after 72 h at 37 °C. Approximately 70% release was observed within 15 min at 80 °C, while the complex maintained stability at 40 °C. The superparamagnetic mNPs generated localized heating under an alternating current magnetic field (192 kHz, 480 A), raising the solution temperature by 6 °C within 5 min. The biotin-maleimide complex demonstrated higher release by rDA from furan-containing mNPs (approximately 150 μM) compared to the control group (approximately 103 μM). These results highlight DiMaN as a promising platform for magnetic-controlled, on-demand drug release.
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