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Related Concept Videos

Conjugated Proteins02:50

Conjugated Proteins

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Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
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Related Experiment Video

Updated: Jan 14, 2026

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
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Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications.

Ellie Martin1,2,3, Sean P Doidge1,2,3, Eiman Aleem2

  • 1College of Technology and Environment, School of Engineering and Design, London South Bank University, 103 Borough Road, London, SE1 0AA, UK.

Advanced Healthcare Materials
|October 24, 2025
PubMed
Summary
This summary is machine-generated.

This review explores novel bioconjugation materials and applications beyond simple substrates. It highlights advancements in targeted therapeutics, diagnostics, and medical innovations using unique biological, hybrid, and synthetic materials.

Keywords:
bioconjugationbio‐bio conjugationdiagnosticsnanozymesnovel materialstargeted therapy

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Area of Science:

  • Bioconjugation chemistry
  • Materials science
  • Biomedical engineering

Background:

  • Bioconjugation is crucial for targeted therapeutics and diagnostics.
  • Existing reviews often focus on common substrates like nanoparticles and polymers.
  • There is a need to explore novel materials in bioconjugation.

Purpose of the Study:

  • To review bioconjugation techniques utilizing novel materials.
  • To explore diverse applications of these advanced bioconjugates.
  • To compare characterization methods and provide future perspectives.

Main Methods:

  • Literature review focusing on recent advancements in bioconjugation.
  • Categorization of novel substrates: biological, hybrid, and synthetic.
  • Analysis of applications and characterization techniques.

Main Results:

  • Identified novel materials including viral capsids, live cells, hybrid nanoparticles, and advanced synthetic materials.
  • Explored applications in cancer therapy, diagnostics, tissue engineering, and advanced imaging.
  • Compared various characterization techniques for bioconjugate validation.

Conclusions:

  • Bioconjugation with novel materials offers transformative potential for medical innovation.
  • Continued development in materials and characterization will drive future advancements.
  • This review provides a comprehensive overview for researchers in the field.