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Updated: Jan 14, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
[Irritable Bowel Syndrome]
Boram Cha1, Jeong Eun Shin2, Woori Na3
1Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea.
Abstract:
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent abdominal pain in the absence of detectable organic, systemic, or metabolic disease. According to the Rome IV criteria, symptoms must have begun at least six months before and be present during the preceding three months for diagnosis. The proposed mechanisms underlying IBS include abnormal intestinal motility, visceral hypersensitivity, altered brain-gut interactions, low-grade mucosal inflammation, immune dysregulation, genetic predisposition, and gut microbiota imbalance. Although many patients report food-related symptom triggers, the relationship between dietary or lifestyle factors and IBS is unclear. The Diet, Obesity, and Metabolism of the Korean Society of Neurogastroenterology and Motility addressed this gap by developing visual educational materials on dietary and lifestyle strategies for functional gastrointestinal disorders. This review summarizes the section devoted to IBS and provides a comprehensive overview of its practical recommendations for clinicians and patients.
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