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Updated: Jan 14, 2026
A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Published on: March 17, 2023
Near-infrared-activated Ru(II)-nile blue conjugates as type-I photosensitizers for efficient hypoxia tumor therapy
Pengmin Shi1, Zhiyuan Zhou1,2, Yanyan Sun3
1Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China. jzhao@seu.edu.cn.
Abstract:
Two cyclometalated Ru(II) complexes functionalized with a modified Nile Blue derivative were developed as near-infrared (NIR)-activated photosensitizers. These complexes efficiently generate superoxide anion radicals (O2˙-) via a type-I mechanism upon irradiation with highly-penetrating 730 nm light, and exhibit outstanding tumor cell-killing efficacy under hypoxic conditions, highlighting their potential for addressing the therapeutic challenges of oxygen-deprived solid tumors.
