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Transcriptome-Based Identification of Biomarkers Associated With Sphingosine-1-Phosphate Signaling Pathway in Aortic

Anmin Li1, Xiu Chen2, WenKao Huang1

  • 1Department of Cardiovascular Surgery, Lihuili Hospital Affiliated to Ningbo University, Ningbo 315000, Zhejiang, China.

International Journal of Hypertension
|October 24, 2025
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This study identifies ITGA5 as a novel biomarker for sphingosine-1-phosphate (S1P)-associated aortic dissection (AD). ITGA5 and CXCL5 show potential for AD diagnosis and treatment, with ITGA5 linked to S1P levels.

Keywords:
CXCL5ITGA5aortic dissectionsphingosine 1-phosphate

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Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Biomarker Discovery

Background:

  • Aortic dissection (AD) is a life-threatening condition.
  • Sphingosine-1-phosphate (S1P) plays a role in AD pathogenesis.
  • Identifying reliable biomarkers for AD is crucial for improved diagnosis and treatment.

Purpose of the Study:

  • To explore sphingosine-1-phosphate (S1P)-related biomarkers in aortic dissection (AD).
  • To identify novel diagnostic and therapeutic targets for AD.
  • To elucidate the molecular mechanisms underlying S1P-associated AD.

Main Methods:

  • Differential gene expression analysis and weighted gene coexpression network analysis (WGCNA) were performed on the GSE153434 dataset.
  • Protein-protein interaction (PPI) network construction and machine learning were used for candidate gene screening.
  • Gene set enrichment analysis (GSEA), immune infiltration analysis, regulatory network analysis, and drug prediction were conducted. Human plasma S1P levels were quantified, and an AD rat model was established for validation.

Main Results:

  • ITGA5 and CXCL5 were identified as key biomarkers for S1P-associated AD.
  • ITGA5 expression was validated in a rat model of AD, showing high expression in dissected aortic tissue.
  • Elevated S1P levels were confirmed in human plasma, and specific immune cell populations were significantly altered in AD patients. CXCL5 correlated positively with central memory CD4 T cells.

Conclusions:

  • ITGA5 is a novel biomarker for S1P-associated aortic dissection.
  • The study provides insights into the molecular mechanisms and potential therapeutic strategies for AD.
  • These findings lay the groundwork for improved diagnostic and therapeutic approaches for AD.