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Updated: Jan 14, 2026
Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
Published on: October 18, 2011
NTCP Modeling of Visual Processing Speed Impairment and Related Factors Following Radiotherapy in Patients with Brain
Zahra Roozmand1, Mohammad Ali Boroomand2, Farzan Madadizadeh3
1Department of Medical Physics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Background:
There have been numerous reports of impairment in neurocognitive functions, including visual processing speed (VPS), among patients who have developed brain metastasis. Therefore, this study aims to develop a model that calculates the probability of normal tissue complication arising from VPS impairment after whole-brain radiotherapy.
Materials And Methods:
In this study, 18 patients were examined for VPS impairment at the 4-month follow-up. After the hippocampus delineation, dose-volume histograms (DVHs) were generated. Normal tissue complication probability (NTCP) models were calculated for VPS using the Lyman model and multivariable logistic regression analysis.
Results:
VPS was observed in 33.3% of patients. TD50 was obtained at 38.43 Gy. The most predictive variable in univariate analysis was VTot, but none of the dosimetric and clinical variables were selected as predictive variables in the multivariate regression analysis (P > 0.05). The overall predictive performance of both models was satisfactory; however, multivariate logistic regression was superior.
Conclusion:
This study modeled the probability of VPS following irradiation of the hippocampus. The NTCP curve showed that by keeping a maximum dose of hippocampi less than 20 Gy, NTCP becomes <25%.
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