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Beyond preclinical promise: can mesenchymal stromal cell-derived extracellular vesicles reliably target tubular

Linrong Pan1,2, Sergio G Garcia1,2, Miriam Font-Morón1

  • 1REMAR-IGTP Group Germans Trias i Pujol Research Institute (IGTP) and Nephrology Department, University Hospital Germans Trias i Pujol (HUGTiP), Badalona 08916, Spain.

Extracellular Vesicles and Circulating Nucleic Acids
|October 24, 2025
PubMed

Insights

Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) show promise for treating kidney disease by protecting renal tubular epithelial cells (TECs). This review explores MSC-EVs

Area of Science:

  • Nephrology and Regenerative Medicine
  • Cell Biology and Extracellular Vesicles

Background:

  • Kidney disease, including acute kidney injury (AKI) and chronic kidney disease (CKD), is a significant global health issue.
  • Damage to renal tubular epithelial cells (TECs) is central to kidney disease pathogenesis, leading to fibrosis.
  • TECs are a key therapeutic target for novel treatments.

Purpose of the Study:

  • To review the literature on targeting TECs with MSC-EVs for kidney disease.
  • To analyze the efficacy of MSC-EVs in both in vitro and in vivo models.
  • To discuss the potential and limitations of MSC-EV-based therapies for TEC protection.

Main Methods:

  • Systematic literature review of studies investigating MSC-EVs and TECs.
  • Analysis of in vitro and in vivo experimental data.
  • Critical evaluation of current research findings.

Main Results:

  • MSC-EVs demonstrate beneficial effects on TECs in various kidney disease models.
  • Evidence supports targeted mechanisms by which MSC-EVs protect TECs.
  • The literature indicates significant therapeutic potential for MSC-EVs.

Conclusions:

  • MSC-EVs represent a promising cell-free therapeutic strategy for kidney diseases.
  • Targeting TECs with MSC-EVs offers a viable approach for regenerative medicine in nephrology.
  • Further research and clinical trials are needed to optimize MSC-EV applications.
Keywords:
Kidney diseasebiodistributionextracellular vesiclesmesenchymal stem/stromal cellstargetingtubular epithelial cells

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