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Coupling of stemness maintenance with cell cycle control in stem cells
Xia Huang1, Yujie Wang1, Qiushuang Li1
1College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China.
Frontiers in Cell and Developmental Biology
|October 24, 2025
Summary
Cell cycle regulation is crucial for maintaining stem cell self-renewal and pluripotency. Understanding these mechanisms, including signaling pathways and metabolism, is key for regenerative medicine applications.
Area of Science:
- Stem cell biology
- Cell cycle regulation
- Regenerative medicine
Background:
- Stem cells possess self-renewal and differentiation potential vital for tissue repair.
- Cell cycle control is increasingly recognized as a key regulator of stem cell fate.
- Unique cell cycle features in stem cells, like embryonic stem cells (ESCs), are linked to self-renewal.
Purpose of the Study:
- To review the molecular mechanisms linking cell cycle regulation to stemness maintenance.
- To explore the role of cell cycle regulators, signaling pathways, and metabolism in stem cell fate.
- To discuss the implications for clinical applications in regenerative medicine.
Main Methods:
- Literature review focusing on cell cycle regulatory networks (Cyclins, inhibitors).
- Analysis of pluripotency factors, cell cycle proteins, and signaling pathways (Jak1/Stat3, PI3K/Akt, Hippo/YAP).
- Examination of epigenetic regulation, metabolism (glycolysis, one-carbon), and cell cycle regulators (p53) in stem cell reprogramming and differentiation.
Main Results:
- Cell cycle patterns are species-specific and linked to pluripotency states.
- Core pluripotency factors and cell cycle proteins significantly influence stem cell fate.
- Epigenetic modifications and unique metabolic pathways in stem cells are intertwined with proliferation and gene expression.
Conclusions:
- Elucidating cell cycle-stemness connections is critical for stem cell therapies.
- Cell cycle regulators play roles in somatic cell reprogramming and adult stem cell fate.
- Strategies based on cell cycle regulation offer promise and challenges for regenerative medicine.
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