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RETRACTION: Dieckol Prevents Prostate Cancer Cell Proliferation by Transcriptionally Attenuating JAK/STAT3 Signaling

    Environmental Toxicology
    |October 24, 2025
    PubMed
    Abstract

    Insights

    This study on Dieckol and prostate cancer cell proliferation has been retracted due to a compromised peer review process. The findings regarding the JAK/STAT3 signaling pathway are therefore invalid.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Toxicology

    Background:

    • Prostate cancer remains a significant health concern, necessitating research into novel therapeutic agents.
    • The Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling pathway is implicated in various cancers, including prostate cancer.

    Purpose of the Study:

    • To investigate the potential of Dieckol, a natural compound, in preventing prostate cancer cell proliferation.
    • To elucidate the molecular mechanisms underlying Dieckol's effects, specifically focusing on the JAK/STAT3 signaling pathway.

    Main Methods:

    • The study aimed to assess Dieckol's impact on prostate cancer cell lines.
    • Investigated the transcriptional regulation of the JAK/STAT3 signaling pathway in response to Dieckol treatment.

    Main Results:

    • Dieckol was reported to prevent prostate cancer cell proliferation.
    • The compound was suggested to attenuate the JAK/STAT3 signaling pathway at the transcriptional level.

    Conclusions:

    • The findings suggested Dieckol as a potential agent for prostate cancer prevention.
    • The JAK/STAT3 signaling pathway was identified as a key target for Dieckol's anti-proliferative effects.

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