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Related Experiment Video

Updated: Jan 14, 2026

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
08:37

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Elevated Alcohol Consumption and Chronic Inflammation Predict Cardiovascular Risk Among Black Americans: Examination

Steven R H Beach1,2, Robert A Philibert3, Mei-Ling Ong1

  • 1Center for Family Research, The University of Georgia, Athens, GA 30602, USA.

Epigenomes
|October 24, 2025
PubMed
Summary

Elevated alcohol consumption (EAC) is a significant predictor of increased cardiac risk over time in middle-aged adults. This finding highlights a potential target for preventative interventions to reduce heart disease disparities.

Keywords:
agingalcohol consumptioncardiac riskinflammation

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Area of Science:

  • Cardiovascular Health
  • Health Disparities
  • Biomarkers of Health

Background:

  • Heart disease disproportionately affects Black Americans compared to White Americans, even with similar traditional risk factors.
  • Elevated alcohol consumption (EAC) and chronic inflammation are potential contributing factors to cardiovascular health disparities.
  • Understanding these additional risk factors is crucial for addressing racial inequities in heart disease outcomes.

Purpose of the Study:

  • To investigate the association between elevated alcohol consumption (EAC), chronic inflammation, and cardiac risk in a cohort of Black American couples.
  • To determine if EAC and chronic inflammation predict future cardiac risk.
  • To explore the longitudinal relationship between changes in EAC, inflammation, and cardiac risk over time.

Main Methods:

  • Recruited couples with a Black preadolescent or early adolescent child.
  • Collected biological samples to measure EAC, chronic inflammation, and cardiac risk using DNA methylation indices.
  • Analyzed data from 661 person-wave observations across two waves of data collection.

Main Results:

  • Elevated alcohol consumption (EAC) at wave 5 predicted increased cardiac risk at wave 6 (R² change = 0.276, p = 0.001).
  • Chronic inflammation did not significantly predict baseline cardiac risk, but the change in inflammation over time was associated with the change in cardiac risk (R² change = 0.111, p < 0.001).
  • Changes in EAC were not significantly associated with changes in cardiac risk over the study period.

Conclusions:

  • Elevated alcohol consumption (EAC) may be an important risk factor for developing increased cardiac risk in middle age.
  • EAC represents a potential target for preventative interventions aimed at reducing cardiac risk and addressing health disparities.
  • Further research is needed to confirm these associations in diverse racial and ethnic groups.