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Updated: Jan 14, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

757

RETRACTION: Curcumin Inhibits Esophageal Squamous Cell Carcinoma Progression Through Down-Regulating the

    Environmental Toxicology
    |October 24, 2025
    PubMed
    Abstract

    Insights

    This study investigated curcumin's effect on esophageal squamous cell carcinoma. However, the article has been retracted due to a compromised peer review process and data duplication concerns.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Toxicology

    Background:

    • Esophageal squamous cell carcinoma (ESCC) is a significant global health concern.
    • Curcumin, a compound found in turmeric, has demonstrated potential anti-cancer properties.
    • Understanding the molecular pathways involved in ESCC progression is crucial for developing effective treatments.

    Purpose of the Study:

    • To investigate the inhibitory effects of curcumin on esophageal squamous cell carcinoma progression.
    • To elucidate the molecular mechanisms underlying curcumin's action, specifically focusing on the circNRIP1/miR-532-3p/AKT pathway.

    Main Methods:

    • The study utilized various experimental techniques to assess curcumin's impact on ESCC cells.
    • Specific molecular assays were employed to analyze the circNRIP1/miR-532-3p/AKT pathway.

    Main Results:

    • The original study reported that curcumin down-regulates the circNRIP1/miR-532-3p/AKT pathway, inhibiting ESCC progression.
    • Specific data presented in the article, including flow cytometry analysis, showed strong resemblance to previously published data under different conditions.

    Conclusions:

    • The article has been retracted due to a compromised peer review process and concerns regarding data integrity.
    • The editors no longer have confidence in the conclusions reported in the retracted article.

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