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Published on: September 28, 2019
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Dual Structural Role of Niobium in Bioactive Borate Glasses Modulates Bioactivity, Cytocompatibility, and Hemostatic
Mariana Sversut Gibbin1,2, Vitor Santaella Zanuto1, Jose G Munguia-Lopez2,3
1Departamento de Física, Universidade Estadual de Maringá, Maringá, PR 87020-900, Brazil.
ACS Applied Materials & Interfaces
|October 24, 2025
Summary
Niobium pentoxide (Nb2O5) in borate glasses acts as both a network former and modifier, influencing structure, reactivity, and biological performance. This dual role allows tailoring bioactive glass properties for biomedical applications.
Area of Science:
- Materials Science
- Biomaterials Engineering
- Glass Chemistry
Background:
- Designing bioactive glasses requires understanding how composition affects structure-property relationships.
- Network modifiers play a crucial role in tuning glass behavior for specific applications.
Purpose of the Study:
- To investigate the effect of niobium pentoxide (Nb2O5) incorporation on the structure and multifunctional biological performance of melt-derived borate glasses.
- To elucidate the dual structural role of Nb in borate glasses and its impact on material properties.
Main Methods:
- Synthesis of borate glasses with varying Nb2O5 content (0-10 wt%).
- Comprehensive characterization using physical, thermal, and vibrational techniques.
- Assessment of surface reactivity, ion release, hydroxycarbonate apatite formation, cytocompatibility, and hemostatic potential.
Main Results:
- Nb2O5 acts as a network former at <=5 wt% and a modifier at higher concentrations, altering glass network connectivity.
- Nb incorporation influenced hardness, elastic modulus, surface reactivity, and ion release.
- Nb-containing glasses showed maintained or enhanced cytocompatibility but reduced hemostatic potential.
Conclusions:
- The dual structural role of Nb in borate glasses offers a strategy for tailoring multifunctional properties for biomedical applications.
- Understanding Nb's influence provides insights into designing advanced bioactive materials.
- Nb incorporation modulates key properties like bioactivity and cell interaction.
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