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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Structural Revision of Aromadendrane Diterpenoids and Sesquiterpenoids from Olibanum Based on DFT Calculations and
Bingyang Zhang1, Hongqin Liu1, Linghui Shi1
1Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Abstract:
The structural revision of aromadendrane diterpenoids and sesquiterpenoids derived from olibanum is reported. Boscartols Q-T (4-7), four new aromadendrane diterpenoids and sesquiterpenoids along with five previously described analogues (1-3, 8-9), were isolated from the gum resin of Boswellia sacra. Configurational revision assigned boscartols O, N, and P to compounds 1-3, respectively. Their structures were determined by the analysis of spectroscopic data, GIAO NMR/DP4+ analyses, ECD calculations, and a single-crystal X-ray diffraction study. Among these compounds, 1-3 and 6 showed moderate inhibitory activity against lipopolysaccharide (LPS)-induced NO production in RAW 264.7 monocyte macrophages relative to the positive control. Meanwhile, compounds 1, 5, and 7 demonstrated cytoprotective activity in L929 mouse fibroblast cells against H2O2-induced oxidative damage at 50 μM.
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