Association between thyroid hormone and cardiovascular health: A cross-sectional study

Area of Science:

• Endocrinology
• Cardiovascular Medicine
• Public Health

Background:

• Limited large-scale human data exists on thyroid hormones and cardiovascular health.
• The American Heart Association's Life's Essential 8 (LE8) is a key metric for cardiovascular health assessment.
• This study investigates the relationship between thyroid hormones and LE8.

Purpose of the Study:

• To explore the association between thyroid hormone levels and the Life's Essential 8 (LE8) cardiovascular health score.
• To understand how thyroid function impacts overall cardiovascular wellness.
• To identify potential links between thyroid health and cardiovascular risk factors.

Main Methods:

• Utilized data from the National Health and Nutrition Examination Survey (2007-2012).
• Included participants aged 20 and above.
• Employed weighted multivariate linear regression, restricted cubic spline curves, and stratified analysis to examine thyroid hormone and LE8 associations.

Main Results:

• Elevated free triiodothyronine (FT3), total triiodothyronine (TT3), and thyroglobulin (Tg) levels were associated with lower LE8 scores.
• Nonlinear relationships were observed between thyroglobulin (Tg), thyroglobulin antibodies (TgAb), and thyroid peroxidase antibodies (TPOAb) with LE8.
• In individuals with normal thyroid function, TT3, thyroxine (TT4), and Tg levels correlated with LE8.

Conclusions:

• Thyroid hormone variations (FT3, TT3, TT4, Tg, TgAb, TPOAb) correlate with changes in LE8 scores.
• Recommendations for cardiovascular health may play a role in maintaining thyroid health.
• Further research is warranted to elucidate the complex interplay between thyroid function and cardiovascular well-being.