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Published on: August 16, 2018
A new sesquiterpenoid from the roots of Nardostachys jatamansi (D.Don) DC
Mehak Sharma1,2, Anmol1, Upendra Sharma1,2
1C-H Activation & Phytochemistry Lab, Chemical Technology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India.
Abstract:
Five molecules, including a new sesquiterpenoid (3aR,5R,8aR)-5-isopropyl-8a-methyl-8-methyleneoctahydroazulen-3a(1H)-ol (1), valeranone (2), 4β,5β-dihydroxy-10-epi-eudesmane (3), halanpinol (4) and β-sitosterol (5), have been isolated from the roots of Nardostachys jatamansi (D.Don) DC. Compounds 2 and 3 have been reported for the first time from this plant species. The structure elucidation of these five molecules has been established based on 1D, 2D NMR and HRESIMS-based spectroscopic data analysis. All the isolated compounds were subjected to in silico molecular docking studies against multiple acetylcholinesterase proteins. Further in vitro potential of the compounds was also evaluated.
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