Related Experiment Video
Updated: Jun 1, 2026

In Vitro Application of a Wireless Sensor in Flexion-Extension Gap Balance of Unicompartmental Knee Arthroplasty
Published on: May 5, 2023
Surgical management of Kienböck's disease with non-negative ulnar variance: A systematic review
Paniz Motaghi1, Duncan Coffey2, Michael Elvey2
1St George's University Hospital, Blackshaw Road, Tooting London, Greater London SW17 0QT, United Kingdom.
Background:
Kienböck's disease is a complex disorder characterized by avascular necrosis of the lunate, influenced by variations in vascular anatomy and abnormal carpal loading. Management remains challenging, particularly in patients with neutral or positive ulnar variance, where standard radial shortening is biomechanically inappropriate. The present systematic review evaluates reported surgical strategies for Kienböck's disease in this population, comparing isolated capitate shortening osteotomy with combined intracarpal procedures and exploring the adjunctive role of vascularized bone grafting.
Methods:
A systematic review was conducted according to PRISMA guidelines. Electronic databases (PubMed, Cochrane Library and Google Scholar) were searched using predefined keywords related to Kienböck's disease and ulnar variance. Owing to heterogeneity of study design and outcome measures, quantitative pooling was not feasible; data were synthesized descriptively. Extracted variables included patient demographics, surgical technique, disease stage, functional and radiological outcomes, and complications.
Results:
Thirteen studies involving 293 patients met the inclusion criteria. The majority were Level IV case series reflecting the rarity of this clinical entity. Isolated capitate shortening osteotomy, performed in 125 patients, demonstrated favorable pain relief and functional improvement, with persistent pain and revision rates of 10.4% and 5.6% respectively. Radial wedge osteotomy yielded mixed results, while isolated core decompression provided short-term benefit in limited cases. Combined decompression and revascularization procedures appeared most beneficial in stage IIIA disease, although comparative evidence remains inconsistent.
Conclusion:
The evidence base for managing Kienböck's disease in non-ulnar-negative wrists is limited and heterogeneous. Isolated capitate shortening osteotomy appears to offer reliable symptomatic relief in early and mid-stage disease, whereas combined approaches may be considered in selected advanced cases. These conclusions should be interpreted cautiously given the predominance of low-level evidence. Further multicenter prospective studies are needed to clarify optimal surgical strategies and refine stage-specific treatment algorithms.
Related Concept Videos
Gene Conversion
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Mismatch Repair
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Mutations in Microorganisms

