Related Experiment Video
Updated: Jul 14, 2026
Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
Published on: April 18, 2015
Contrast-enhanced endoscopic ultrasound versus conventional endoscopic ultrasound-guided fine-needle biopsy with
Charing C N Chong1, Dario Ligresti2, Tae Hyeon Kim3
1Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Background And Aims:
Although contrast-enhanced EUS (CE-EUS) has been suggested to improve the diagnostic yield of EUS-guided fine-needle aspiration (FNA) of solid pancreatic lesions (SPLs), multicenter data to inform its use in fine-needle biopsy (FNB) remain scarce. This multicenter randomized trial aims to compare the diagnostic performance of CE-EUS and conventional EUS-guided FNB with macroscopic on-site evaluation (MOSE) for SPLs.
Methods:
Consecutive patients with SPLs ≥1 cm from 3 referral centers (Hong Kong, Italy, and Korea) were randomized to CE-EUS or conventional EUS-guided FNB with MOSE. Outcome measures were false-negative rate, sensitivity, specificity, accuracy, procedural time, and procedure-related adverse events of assigned technique.
Results:
One hundred twenty-eight patients were randomized between February 2022 and August 2023. B-mode EUS identified avascular areas in 25.0% of SPL in the CE-EUS group and 20.3% of SPL in the conventional EUS group (P = .526). CE-EUS further increased avascular area detection in SPLs from 25.0% to 31.3%. The false-negative rate (6.0% vs 7.9%, P > .999), sensitivity (94.0% vs 92.1%, P > .999), specificity (100% vs 100%, P > .999), diagnostic accuracy (95.3% vs 92.2%, P = .718), number of passes to achieve macroscopic visible core length ≥4 mm (1 vs 1.5, P = .480), and mean macroscopic visible core length (16.8 mm vs 20.6 mm, P = .259) were similar in both groups.
Conclusions:
In this multicenter study, CE-EUS and conventional EUS-guided FNB with MOSE had similarly low false-negative rates and high diagnostic accuracies for SPLs. Routine use of CE-EUS did not further improve FNB yield in SPLs when dedicated FNB needles were used.
