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Updated: Jan 14, 2026

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Exploring microgravity-induced changes to the coagulation system using thrombelastograph - a topical review.

Ivy Mayor1, Karsten Lindgaard2, Bijan Harandi3

  • 1Department of Cellular and Molecular Biology, Karolinska Institute, Sweden.

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|October 24, 2025
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Microgravity may increase blood clot risk in astronauts. Thrombelastography (TEG) can assess coagulation changes, crucial for spaceflight safety and diverse populations.

Keywords:
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Area of Science:

  • Space Medicine
  • Hematology
  • Physiology

Background:

  • A 2020 case identified an internal jugular venous thrombus in an astronaut post-microgravity exposure.
  • Microgravity may induce hypercoagulable states via altered blood composition, venous flow, and endothelial dysfunction.
  • Current understanding of microgravity's impact on blood coagulation and thromboembolic (TE) risk is limited, with no direct studies in space.

Purpose of the Study:

  • To investigate the effects of microgravity on blood coagulation dynamics using thrombelastography (TEG).
  • To assess the potential for microgravity to induce a hypercoagulable state and increase TE risk.
  • To inform strategies for astronaut health and safety in future space missions.

Main Methods:

  • Utilizing thrombelastography (TEG) to comprehensively assess whole blood coagulation dynamics.
  • Analyzing coagulation parameters to identify changes indicative of a hypercoagulable state.
  • Extrapolating findings from previous bedrest studies to the context of microgravity.

Main Results:

  • TEG offers a holistic assessment of coagulation, unlike traditional assays.
  • Previous bedrest studies provided insights but did not show significant TEG differences.
  • The direct impact of true microgravity on coagulation remains to be elucidated.

Conclusions:

  • Understanding microgravity's effect on coagulation is vital for astronaut safety.
  • TEG can provide critical insights into microgravity-induced coagulation changes and TE risk.
  • This research is essential for preventive strategies in long-duration spaceflight and diverse populations.