Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

2.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.8K
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

317
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
317
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

707
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
707
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

678
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
678
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

473
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
473
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

215
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
215

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estimated Stressed Blood Volume in Patients With Cardiac Amyloidosis.

The American journal of cardiology·2026
Same author

Heart and heart-liver transplantation in Amish patients with propionic acidemia.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2026
Same author

Impact of Baseline Renal Function on Waitlist Outcomes in Patients Supported With Impella as a Bridge to Heart Transplantation.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same author

HDL-C: Helpful, harmful, hopeful, or guilty by association.

Journal of clinical lipidology·2025
Same author

In-Hospital Management of Acute Heart Failure.

The Medical clinics of North America·2025
Same author

Heart Failure Evaluation and Care: Acute and Chronic Disease.

The Medical clinics of North America·2025
Same journal

Care Transitions Continue to Evolve.

The Medical clinics of North America·2026
Same journal

Navigating the Gaps: A Comprehensive Overview of Care Transitions Across the Continuum.

The Medical clinics of North America·2026
Same journal

Care Transitions and Value-Based Payment Models in the United States.

The Medical clinics of North America·2026
Same journal

Technology and Innovation in Care Transitions: Imagining the Future of Postdischarge Care.

The Medical clinics of North America·2026
Same journal

Primary Care, Specialists, and Hospitals: Bridging the Gaps in Communication and Coordination.

The Medical clinics of North America·2026
Same journal

Social Determinants of Health: Unique Considerations in Transitions of Care.

The Medical clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Jan 14, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.0K

Heart Failure with Preserved Ejection Fraction.

Daniel Mathew1, Yasmine Elghoul2, Sanjeeb Bhattacharya2

  • 1Department of Medicine, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA 30322, USA.

The Medical Clinics of North America
|October 24, 2025
PubMed
Summary
This summary is machine-generated.

Heart failure with preserved ejection fraction (HFpEF) presents diagnostic challenges. Current clinical guidelines and trials offer some management strategies but require further development for this complex heart condition.

Keywords:
ComorbiditiesDiagnostic uncertaintyDiastolic dysfunctionGuideline-directed medical therapyHeart failure with preserved ejection fraction

More Related Videos

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
07:09

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Published on: February 18, 2022

2.3K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

2.0K

Related Experiment Videos

Last Updated: Jan 14, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.0K
A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
07:09

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Published on: February 18, 2022

2.3K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

2.0K

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome characterized by heart failure symptoms with normal left ventricular ejection fraction.
  • Diagnosing HFpEF is complex, often necessitating the exclusion of other conditions mimicking its symptoms.

Purpose of the Study:

  • To summarize the diagnostic challenges and current management landscape for HFpEF.
  • To highlight the existing clinical practice guidelines and clinical trials for HFpEF management.

Main Methods:

  • Review of existing literature on HFpEF diagnosis and management.
  • Analysis of current clinical practice guidelines and trial data.

Main Results:

  • Diagnostic evaluation for HFpEF is extensive and aims to rule out alternative causes of symptoms.
  • Clinical trials targeting HFpEF management have been conducted.
  • Clinical practice guidelines for HFpEF exist but offer less robust recommendations compared to other heart failure types.

Conclusions:

  • HFpEF diagnosis requires a comprehensive approach due to its complexity.
  • While management strategies and guidelines exist, further research and stronger recommendations are needed for HFpEF.