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Updated: Jan 14, 2026

Evaluation and Manipulation of Neural Activity Using Two-Photon Holographic Microscopy
Published on: September 16, 2022
Explore brain-inspired machine intelligence for connecting dots on graphs through holographic blueprint of
Tingting Dan1, Jiaqi Ding1,2, Guorong Wu3,4,5,6
1Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
None:
Neural coupling in both neuroscience and AI emerges dynamic oscillatory patterns that encode abstract concepts. To that end, we hypothesize that a deeper understanding of the neural mechanisms that determine brain rhythms could inspire next-generation design principles for machine learning algorithms, leading to greater efficiency and robustness. Following this notion, we first model the evolving brain rhythm by the interference between spontaneously synchronized neural oscillations (termed HoloBrain). The success of modeling brain rhythms via an artificial dynamic system of coupled oscillations gives rise to the "first principle" for emerging brain-inspired machine intelligence through the common mechanism of synchronization (termed HoloGraph), enabling graph neural networks (GNNs) to move beyond conventional heat diffusion paradigms toward modeling oscillatory synchronization. Our HoloGraph not only effectively addresses the over-smoothing issue in GNNs but also manifests the potential of reasoning and solving challenging problems on graphs.
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