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Jonathan R Clark^1,2,3,4,5, D S Abdullah Al Maruf^6,7, Eva Tomaskovic-Crook^8,9,10

¹NHMRC Centre of Research Excellence for Applied Innovations in Oral Cancer, Camperdown, NSW, Australia. jonathan.clark@lh.org.au.

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Summary

This study presents a novel 3D-printed polyetherketone scaffold for long-term bone regeneration in ovine mandibles. This approach offers a durable alternative to traditional bone grafts and metal plates.

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Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Area of Science:

Biomaterials Science
Regenerative Medicine
Orthopedic Surgery

Background:

Critical-sized bone defects pose significant clinical challenges.
Current treatments using bioresorbable scaffolds and metal plates have limitations, including mechanical instability, stress shielding, and interference with imaging and radiotherapy.
Mandibular reconstruction, especially in ovine models, is complicated by high mechanical stresses.

Purpose of the Study:

To evaluate a novel, permanent, 3D-printed scaffold for long-term reconstruction of segmental mandibular defects.
To assess the efficacy of a patient-matched, numerically optimized polyetherketone gyroid scaffold combined with a ceramic-hydrogel composite in ovine models.

Main Methods:

Utilized a permanent, patient-matched, numerically optimized, 3D-printed, thermally toughened, plasma-treated, and laser-sintered polyetherketone gyroid scaffold.
Integrated a resorbable ceramic lattice infused with a stem cell-laden hydrogel as an osteoinductive reservoir.
Reconstructed ovine segmental mandibulectomy defects and assessed long-term clinical performance.

Main Results:

Achieved long-term reconstruction of ovine segmental mandibulectomy defects.
Demonstrated durable clinical performance of the novel scaffold system.
The scaffold provided a stable and effective solution for challenging mandibular defects.

Conclusions:

The permanent, 3D-printed polyetherketone scaffold offers a translatable alternative to conventional bone grafting and metal plate fixation.
This approach addresses the mechanical and biological challenges in critical-sized bone defect reconstruction.
The study highlights a promising strategy for improving outcomes in mandibular reconstruction.