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The gut feeling in motion sickness.

Tessa M W Talsma1, Ksander N de Winkel

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Summary
This summary is machine-generated.

Motion sickness mechanisms are not fully understood. New research suggests the gut microbiome and enteric nervous system may play a significant role in motion sickness development.

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Area of Science:

  • Neuroscience
  • Gastroenterology
  • Human Physiology

Background:

  • Motion sickness is a common condition triggered by unnatural motion, affecting travel, virtual reality, and space exploration.
  • While brain-to-body signaling is known, the gut's role in motion sickness remains under-explored.
  • Individual susceptibility to motion sickness varies greatly, indicating complex underlying factors.

Purpose of the Study:

  • To explore afferent brain-body pathways in motion sickness.
  • To investigate the potential role of the gut's neuroepithelial cells and microbiome in motion sickness etiology.
  • To propose a novel biological control system influencing motion sickness.

Main Methods:

  • Review of existing literature on efferent and afferent signaling pathways.
  • Analysis of recent findings on the gut microbiome and neuroepithelial cells.
  • Examination of hormonal, immune, and extracellular pathways connecting the brain and gut.

Main Results:

  • Evidence suggests afferent pathways involving the gut contribute to motion sickness.
  • The enteric nervous system may regulate these gut-brain pathways.
  • Humoral agents, enteroendocrine cells, and the gut microbiome are potential initiators.

Conclusions:

  • The gut-brain axis, particularly the enteric nervous system, offers a new perspective on motion sickness.
  • Understanding these pathways could lead to novel treatments for motion sickness.
  • Further research into the gut microbiome's role is warranted.