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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
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Integrated backscatter intravascular ultrasound features of diffuse coronary artery disease with triglyceride-deposit

Takayuki Nakano1, Hiroki Ikenaga1, Ken-Ichi Hirano2

  • 1Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
|October 25, 2025
PubMed

Insights

Triglyceride-deposit cardiomyovasculopathy (TGCV) involves diffuse coronary artery narrowing. This study found TGCV lesions have less lipid area and are linked to worse cardiovascular events in diffuse coronary artery disease patients.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Medical Imaging

Background:

  • Triglyceride-deposit cardiomyovasculopathy (TGCV) is defined by diffuse coronary artery narrowing due to atherosclerosis.
  • Plaque characteristics and prognosis of TGCV in diffuse coronary artery disease (CAD) are not well understood.

Purpose of the Study:

  • To investigate coronary artery morphology in TGCV using integrated backscatter intravascular ultrasound (IB-IVUS).
  • To assess the clinical outcomes associated with TGCV in patients with diffuse CAD.

Main Methods:

  • Retrospective observational study comparing IB-IVUS findings and clinical outcomes.
  • Patients with native coronary lesions of TGCV and non-TGCV with diffuse CAD were analyzed.
  • TGCV diagnosis included low BMIPP washout rate (<10%) and diffuse coronary narrowing.

Main Results:

  • TGCV lesions showed a significantly smaller lipid area ratio (20% ± 0.8%) compared to non-TGCV lesions (23% ± 0.5%, p=0.02).
  • A trend towards a larger calcification area ratio was observed in TGCV.
  • The TGCV group experienced significantly higher rates of major adverse cardiovascular events (p=0.01).

Conclusions:

  • TGCV in diffuse CAD is characterized by a reduced lipid area in coronary lesions.
  • TGCV appears to be associated with poorer clinical outcomes, suggesting a need for early diagnosis and management strategies.

Keywords:
diffuse coronary artery diseaseintravascular ultrasoundpercutaneous coronary interventiontriglyceride-deposit cardiomyovasculopathy

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